Control Design for Signal Transduction Networks
نویسندگان
چکیده
Signal transduction networks of biological systems are highly complex. How to mathematically describe a signal transduction network by systematic approaches to further develop an appropriate and effective control strategy is attractive to control engineers. In this paper, the synergism and saturation system (S-systems) representations are used to describe signal transduction networks and a control design idea is presented. For constructing mathematical models, a cascaded analysis model is first proposed. Dynamic analysis and controller design are simulated and verified.
منابع مشابه
Study of PKA binding sites in cAMP-signaling pathway using structural protein-protein interaction networks
Backgroud: Protein-protein interaction, plays a key role in signal transduction in signaling pathways. Different approaches are used for prediction of these interactions including experimental and computational approaches. In conventional node-edge protein-protein interaction networks, we can only see which proteins interact but ‘structural networks’ show us how these proteins inter...
متن کاملThe Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy
Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...
متن کاملThe Expression of Signal Regulatory Protein-alpha in Normal and Osteoarthritic Human Articular Cartilage and Its Involvement in Chondrocyte Mechano-transduction Response
Signal regulatory proteins (SIRP) belong to immunoglobulin super family (IgSF) and relate to integrin signaling cascades. It has been shown that SIRPa is expressed in a variety of cells including myeloid cells and neurons. In the present study the expression of this IgSF member in articular chondrocytes was investigated. Methods: Using a panel of anti-SIRPalpha antibodies, immunohistochemistry...
متن کاملOptimal Signal Control in Urban Road Networks with High Priority Congested Centers
Keeping the density of traffic flow and air pollution in an acceptable level and developing a good capacity for transit in the high priority areas of the city, is really a big deal in large and crowded cities. To address this problem, a new method of intersection signal optimization is presented in this paper. Based on network fundamental diagrams, an Internal–External Traffic Metering Strategy...
متن کاملDesign principles and control mechanisms of signal transduction networks
This work is based on the hypothesis that signal transduction networks in living cells are the result of an evolutionary development which is governed by mutation mechanisms and natural selection principles. This concerns their structural design as well as kinetic parameters. Therefore, it can be assumed that these properties have adopted values which imply certain optimal features with respect...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2009